Off-the-shelf mesenchymal stromal cells derived from umbilical cord tissue

Investigation of the Osteogenic Potential of Mesenchymal Stromal Cells derived from Human Umbilical Cord Tissue

Galway, Ireland Investigation of the Osteogenic Potential of Mesenchymal Stromal Cells derived from Human Umbilical Cord Tissue Pierre Moretti, Stefanie Boehm, Antonina Lavrentieva, Tim Hatlapatka, Ralf Hass, Thomas Scheper, Cornelia Kasper Corresponding Author: Kasper @iftc.uni-hannover.de 1 Institute of Technical Chemistry, University of Hannover, Hannover, Germany 2 Laboratory of Biochemistr...

What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

MSCs derived from the umbilical cord tissue, termed UCX, were investigated for their immunomodulatory properties and compared to bone marrow-derived MSCs (BM-MSCs), the gold-standard in immunotherapy. Immunogenicity and immunosuppression were assessed by mixed lymphocyte reactions, suppression of lymphocyte proliferation and induction of regulatory T cells. Results showed that UCX were less imm...

Stromal Cells Modulate Monocyte Function Umbilical Cord-Derived Mesenchymal

Differentiation of mesenchymal stromal cells derived from umbilical cord Wharton's jelly into hepatocyte-like cells.

BACKGROUND AIMS Mesenchymal stromal cells (MSC) isolated from bone marrow (BM), adipose tissue and umbilical cord blood can be induced to differentiate into hepatocyte-like cells. MSC can also be isolated from umbilical cord Wharton's jelly (UC MSC), which can be easily obtained. UC MSC are more primitive MSC than those isolated from other tissue sources and do not express the major histocompat...

Mesenchymal stem cells from umbilical cord tissue as potential therapeutics for cardiomyodegenerative diseases – a review

Heart failure is one of the leading causes of death worldwide. End stage disease often requires heart transplantation, which is hampered by donor organ shortage. Tissue engineering represents a promising alternative approach for cardiac repair. For the generation of artificial heart muscle tissue several cell types, scaffold materials and bioreactor designs are under investigation. In this revi...